Abzyme polyclonal IgG activity in patients with early arthrites

Volkova M.V.

The abzyme (DNAse, BAPNA-amidase, catalase and superoxydismutase) activity of polyclonal IgG was assessed in 33 patients with early rheumatoid arthritis, 47 patients with acute reactive arthritis and 39 healthy donors.
The levels of DNAse and superoxydismutase IgG activity in patients with early rheumatoid arthritis and acute reactive arthritis were higher in comparison with the same ones in healthy persons. The patients with early rheumatoid arthritis demonstrated the highest DNAse and superoxydismutase IgG activity level. We revealed the multiply relationships between catalytic polyclonal IgG activity levels, clinical symptoms of early arthrites and laboratory findings in examined patients.
The detection of high DNAse and superoxydismutase IgG activity levels in patients with early arthrites confirms the role of abzymes in their immunopathogenesis, at the same time the assessment of DNAse IgG catalytic activity level has an additional diagnostic significance in differentiation of these pathologies.