The role of peripheral blood gd T cells in idiopathic IgA-nephropathy development and progression

Yurkevich M.Y., Nizheharodova D.B., Zafranskaya M.M.

Belarusian Medical Academy of Post-graduate Education, Minsk, Belarus

The description of proliferative activity, phenotypic and secretory features of circulating gd T cells in idiopathic IgA-nephropathy patients was presented in this study. The research describes the role of this cell population in IgA-nephropathy development, which consists in the high level of CCR7 expression on gd T lymphocytes, cell migration to secondary lymphoid organ, CD40L (CD154)-mediated gd T- and B – cells cooperation and the induction of humoral immune response. The prognostic significance of the low number of circulating gd T cells for the detection of IgA-nephropathy unfavorable course was shown.