Clinical and immunological efficiency of extracorporeal photochemotherapy in lichen planus

Kil’djushevskij A.V., Karaulov A.V., Molochkova Yu.V.

1 M.F. Vladimirskiy Moscow Regional Research Clinical Institute
2 I.M. Sechenov First Moscow State Medical University

There had been carried out a comparative study of the clinical efficacy in two groups of patients with common lichen planus (LP): patients receiving complex therapy, which includes extracorporeal photochemiotherapy (ECP) with routine therapy (40 patients), and patients receiving only routine therapy (delagil, doxycycline and corticosteroid ointments) (40 patients). To obtain representative information, patients of both groups had been divided equally in terms of disease: less and more than 6 months (group I-IV).
On the term of disease less than 6 months ECP contributed to the reduction of opportunities for transendothelial migration of activated CD8 T lymphocytes, and at later stages of LP - to reduction of the activity of natural killer cells.
The obtained information confirms high clinical efficacy of ECP and its pathogenetic validity in early and late stages of LP.