Evaluation of nasal immunoglobulin E levels as a diagnostic tool in atopic diseases

Grigorieva I.N., Manina I.V., Golubtzova N.V., Sergeev A. Yu.

1 Institute of Allergology and Clinical Immunology, Moscow, Russian Federation
2 Central Regional Hospital, Balashikha, Russian Federation
3 Russian Cancer Research Center, Moscow, Russian Federation
4 First Moscow Medical State University, Moscow, Russian Federation

Millions of people are affected by allergy, and the pathogenesis of allergic rhinitis is a well-researched area. The issue of allergy diagnostics is therefore not an issue in the fullest sense of the word. However, there still is place for further research. The detection of nasal immunoglobulin E could be a topic of such. There have been cases when conventional testing methods (e.g. skin prick tests) yielded negative results for patients with prominent clinical symptoms of allergy. There is a likelihood that positive results could be obtained if specific nasal IgE screening test was applied. The poorly examined phenomenon of local allergic rhinitis (a.k.a. entopy), characterized by a presence of clinical symptoms of allergy and negative blood test results, could as well be diagnosed via the detection of specific IgE in nasal secretion and/or tissue of inferior turbinate.