Pathogenetic therapy of infectious complications of penetrating eye injury

Dikinov Z.H., Bashtanenko A.F., Shkalev M.V.

1Medical Faculty of H.M.Berbekov Kabardino-Balkarian State University, Nalchik, Russia
2Modern Medicine Center of Moscow Academy of Labor Market and Information Technologies, Moscow, Russia

The purpose of the paper was to determine the expediency of applying sodium aminodigidroftalazindiona (APH) and hyperbaric oxygenation (HBO) in patients with penetrating eye injury, which was complicated by posttraumatic intraocular infection. The high efficiency of APH was demonstrated in improving clinical outcomes and preventing major complications, which correlated with a rapid decrease in the tear fluid concentrations of tumor necrosis factor, interleukin-1β and neopterin. Addition of HBO in complex therapy potentiated anti-inflammatory effects of APH, which was documented by the influence on molecular markers of intraocular inflammation and the main outcomes/complications of penetrating eye injury.