interaction between thymus and thymic peptides with nervous and endocrine systems

Zimina I.V., Belova O.V., Torhovskaya T.I., Arion V.Ya., Novoseletskaya A.V, Kiseleva N.M., Kruchkova A.V., Inozemtsev A.N., Sergienko V.I.

FSBIS SRI PCM FMBA of Russia, Moscow; ** V.N.Orehovich IBMC RAMN, Moscow, Russia; *** M.V. Lomonosov MSU, Moscow, Russia

Interaction between thymus and thymus peptides with nervous and endocrine systems is discussed. Much attention is paid to the thymus hormone thymulin, its influence on the central nervous and endocrine systems, anti-inflammatory and analgesic properties. Prospects for therapeutic use of thymulin and its gene are described. The effects of thymosins α1 and β4 and prothymosin α on nervous and endocrine systems is reviewed. Neuroprotective and neurorestorative effects of thymosin β4 on damaged nerve cells are mentioned. Thymosin α1 is characterized by its influence on the nerve growth factor production, secretion of hypothalamic releasing hormones and reduction of chemotherapy associated neurotoxicity. The data on prothymosin α expression of in brain, its key role in inhibiting apoptosis and necrosis, induced by ischemia in brain and retina, is discussed. It was shown that the definite amino acid sequences of prothymosin α, consisting of 30 and 9 amino acids, exhibit neuroprotective effect.