Intradermal autologous serum and histamine-enhanced therapy
are highly effective in patients with cold urticaria

Novikov D.K., Velichinskaya V.G.

Vitebsk State Medical University, Vitebsk, Belarus

The purpose of the research - to approve intradermal autoserumhistaminotherapy as a new method of treatment in patients with cold urticaria and compare its efficiency with autoserumtherapy.
Materials and methods. 44 patients with cold urticaria were included in the study. Randomly the patients were divided into 2 groups depending on the therapy type: the first group contained 36 patients treated with аutoserumhistaminotherapy (АSHТ), the second group contained 8 patients treated with аutoserumtherapy (AST).
The results. The positive effect of the treatment was marked in both groups right after the treatment finishing (in 10-14 days of the treatment). It was shown the symptoms reduction and the quality of life improvement. Better treatment results were marked by patients treated with аutoserumhistaminotherapy. They marked the quality of life improvement by all specific criteria given at the «Chronic Urticaria Quality of Life Questionnaire» (CU - Q2oL). The good effect and full disease remission was reached at 91,6 % patients of the first group and 75% patients of the second group after one year supervision. There were 8,4% patients at the first and 25% patients at the second group with the satisfactory and unsatisfactory effects.
Conclusions. Autoserumhistaminotherapy and аutoserumtherapy are highly effective methods of cold urticaria treatment. Autoserumhistaminotherapy has shown better results than аutoserumtherapy.