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International journal of Immunopathology, allergology, infectology.

The whole organizm effects of immunity modulators

Zemskov A.M., Zemskov V.M., Zemskova V.A., Zoloedov V.I.

1 Voronezh State Medical Academy named N.N. Burdenko, Ministry of Health of Russian Federation, Voronezh, Russia
2 FSBO «Institute of Surgery named A.V. Vishnevsky», Moscow, Russia

The authors of the study with a retrospective analysis of published data assessing the immune status of patients with more than 40 nozological forms of disease and the results of the current survey of more than 350 persons suffering from purulent-inflammatory diseases of various origins (deep pyoderma, exacerbation of chronic pyelonephritis, exacerbation of chronic salpingoophoritis) received different variants of immunotherapy, with the following results: - demonstrated the ability of someone combinations of modulators with basic treatment differentially affect not only the immunologic, but also on - metabolic, hematologic, bacteriological, biochemical and clinical characteristics of patients; - using ranking method it is possible to characterize the effectiveness of the resulting integral action of the whole organism options immunotherapy patients and build activity rating of treatment; calculation of the diagnostic value of a set allows to select key parameters studied and thus form the typical formula of disorders in laboratory parameters (FDIS, FBEI), targets correctors (FSI) or "own" independent escort therapeutic effect of drugs (FSIsob.); analysis of the FSI and FSIsob., shows a modification of the mechanism of action of the modulator - sodium nucleinate depending on nozological forms of diseases, basic treatment, use of other immunomodulators.


Pyo-inflammatory diseases, immunotherapy, modulators, immune status, FDIS, FSI.

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Zemskov A.M., Zemskov V.M., Zemskova V.A., Zoloedov V.I. Immunopathology, allergology, infectology 2015; 3:14-24