Specific humoral and cellular immunity in human periodically vaccinated against plague

Firstova V.V., Kalmantaeva O.V., Gorbatov A.A., Кravchenko T.B., Tjurin E.A., Bondarenko N.L., Dyatlov I.A., Karaulov A.V.

1 Federal State Institution of Science State Research Center for Applied Microbiology & Biotechnology, Obolensk, Russia
2 I.M.Sechenov First Moscow State Medical University of Russian Ministry of Health, Moscow, Russia

The paper presents specific humoral and cellular immunity in people periodically vaccinated with live plague vaccine. Antibody titers to F1 antigen in human subjects vaccinated periodically (for more than 20 years) against plague, were low and increased not in all cases after the next vaccination. Changes in lymphocyte activation markers in response to the F1 antigen were analyzed. We found that memory T-lymphocytes specifically increase HLA-DR expression marker on their surface under the influence of the F1 antigen in blood of donors vaccinated against plague.