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International journal of Immunopathology, allergology, infectology.

Determination of androgen receptors in cells of triple negative breast cancer

Krylov A.Y., Krylov Y.V., Yanchanka U.V.

1 Institute of improvement of professional skill and retraining of personnel of the State committee of judicial examinations of Belarus, Minsk, Belarus
2 Vitebsk regional clinical pathoanatomical bureau, Vitebsk, Belarus
3 Vitebsk State Medical University, Vitebsk, Belarus
4 JSC ôScientific-research enterprise Resanö, Vitebsk, Belarus

The presence of androgen receptor (AR) in the cells of triple negative breast cancer was detected immunohistochemically. Androgen receptors were found in 11 (22%) from 50 cases of triple-negative breast cancer. The number of malignant cells with androgen receptor from the total breast cancer cells number was from 1 to 55%, the mean value ľ 25 ▒ 22%.
There were not metastases in regional lymph nodes in any case of the AR+ triple-negative breast cancer. AR+ cells of the triple negative breast cancer metastasize to regional lymph nodes significantly slower compared with AR-cells of the triple negative breast cancer. There were metastases to the regional lymph nodes in 5 cases (12.8%), distant metastases - in 1 case (2.6%) in patients with AR-triple negative breast cancer. The androgen receptors determination in breast cancer cells by immunohistochemistry is prognostically valuable.

Keywords

Androgen receptor, triple-negative breast cancer, monoclonal antibody, immunohistochemistry

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DOI

10.14427/jipai.2016.1.32

Reference

Krylov A.Y., Krylov Y.V., Yanchanka U.V. Immunopathology, allergology, infectology 2016; 1:32-36. DOI: 10.14427/jipai.2016.1.32