Estimation of the human health condition when prognosing infectious inflammatory disease clinical course

Bondarenko N.L., Afanasiev S.S., Alyoshkin V.A., Voropaeva E.A., Bairakova A.L., Afanasiev M.S., Nesvizhsky Y.V., Egorova E.A., Metelskaya V.A., Alyoshkin A.V., Grechishnikova O.G., Rubalskii E.O., Urban Y.N., Voropaev A.D., Stepanov A.V., Evsegneeva I.V., Karaulov A.V.

1 Moscow Scientific Research Institute of Epidemiology and Microbiology n. a. G.N. Gabrichevsky, Moscow
2 Sechenov First Moscow State Medical University, Moscow

Microbiocenosis of the mucous membranes is a very sensitive indicator that responds with quantitative and qualitative changes to any changes of external and internal environment of the body. The mucous membranes of open cavities of the body function as a single organ, and therefore independently from the mucous biotope simultaneously similar changes are registered (same types- degrees) of their microbiocenoses; the localization of the pathological process in the particular biotope of the mucous determines the severity of changes in microbiocenosis, compared to other biotopes of the mucous membranes of the body. It is established that in good health and absence of clinical manifestations on the mucous membranes of open cavities of the macroorganism (as a single functional unit - the organ) type I (degree) microbiotope or type II (degree) microbiotope of mucous membranes is registered; in the prodromal period of an infectious disease type III (degree) of microbiotope or type IV (degree) of microbiotope of mucous membranes is registered. During health disturbance (disease) and clinical manifestations of infectious disease with a favorable course III type (degree) of mucous microbiotope IV or type (degree) of microbiotope is registered; I type (degree) of mucous membranes microbiotope II or type (degree) of mucous membranes microbiotope registration (unfavorable course of the process) indicates the inhibition of anti-infective drug resistance and chronic disease; with the recovery, subsidence of clinical signs and eradication of the pathogen revealed I type (degree) or II type (degree) of mucous microbiotope (a favorable process), and the clinical manifestations (adverse the infectious process)- chronization, detection of type III (degree) of microbiotope or type IV (degree) of mucous microbiotope indicates the need for further treatment.