Immunological phenotypes of intolerance of dental materials

Karpuk I.U.

Vitebsk State Medical University, Vitebsk, Belarus

The purpose of work was the research of the immune status and allocation of immunologic phenotypes at patients with the intolerance of stomatologic materials (ISM).
Examination 91 patients aged from 46 up to 65 years, with complaints to ISM is conducted.
As a result of a research of the T-cellular link of system of immunity at patients with an intolerance of stomatologic materials, but without the taped hypersensitivity to their components, taped the following patterns: statistically reliable (р<0,05) depression of the CD3+ levels of the T-general (47,9±3,7 at norm in control group – 66,2±4,5) and CD4+ of T-helpers (30,6±2,8 at norm of donors 38,2±3,2). It is noted reliable (р<0,05) depression of IRI (1,49±0,32 at norm of donors 1,76±0,36).
At patients with complaints to an intolerance of stomatologic materials and the taped hypersensitivity, by results of application assays and reaction of allergenindutsirovanny damage of leucocytes the immune status was characterized reliable (р<0,05) by rising of quantity of the lymphocytes carrying CD25+ markers for 36,2% in comparison with those in control group (р<0,05). The augmentation of IRI (2,33±0,54) in comparison with control group (1,76±0,36) (р<0,05), generally at the expense of the increased CD4+ level of T-helpers and relative depression the maintenance of CD8+ of T lymphocytes to 18,3±3,6% is established (patients of control group have 21,7±3,09%). At that group depression of the IgA level (р<0,05) in blood serum to 1,36±0,12 g/l and in oral liqid to 0,042±0,0023 g/l is taped, and patients of control group have 2,57±0,06 g/l and 0,11±0,04 g/l respectively.
The lowered activity of neutrocytes by results of spontaneous (8,4±3,5%) and induced (41,4±5,3%) is established to test NST at patients with ISM without hypersensitivity to dental alloys that authentically (р<0,05) differed with similar indicators of patients with ISM and the taped hypersensitivity to components of dental alloys.
Indicators of the increased metabolic activity of neutrophils at patients with complaints to NSM and the taped hypersensitivity to dental alloys and their components defined in the NST-test correlated with: levels IgA of stomatic liquid (r=-0,55; р<0,05); quantity of dentoprosthetic units (r=0,72; р<0,05); terms of use of dentoprosthetic designs (r=0,47; р<0,05).
The data obtained by us show two immunologic phenotypes of ISM: one with a hypersensitivity to them, the second with its absence. At both phenotypes signs of deficiency of local and general immunity which differed at these phenotypes are taped.