The role of Adrb2 gene polymorphisms Arg16Gly and Gln27Glu in the pathogenesis of atopic diseases in children from Belarus

Chakova N.N., Volovik N.O., Niyazova S.S., Bialiayeva L.M., Mikulchyk N.N., Buza D.V., Mytko Yu.A.

Institute of Genetics and Cytology NASB, Minsk, Belarus,
Belarusian Medical Academy of Post-Graduate Education, Minsk, Belarus

The aim of the study was to investigate the role of ADRB2 gene polymorphism in the pathogenesis of atopic diseases in children from Belarus. A total of 276 children with atopic BA, 111 patients with atopic dermatitis and control sample from Belarus were analyzed. PCR-RFLP method was used for studying polymorphisms Arg16Gly (rs1042713) and Gln27Glu (rs1042714) of the ADRB2 coding β2-adrenoreceptor. The association of the 16Gly allele of polymorphic variant Arg16Gly with an increased risk of atopic diseases was found (OR = 1.28, 95% CI 1.01–1.63). The genotype 16ArgArg is protective for the development of pathology (OR = 0.48, 95% CI 0.29–0.79). The association of the genotype 27GluGlu of polymorphism Gln27Glu with predisposition to atopic dermatitis (OR = 1.89, 95% CI 1.09–3.30) and a decrease in the probability of bronchial asthma addition (OR = 0.47, 95% CI 0.28–0.80) was revealed. The results obtained can be used to predict the atopic diseases onset and course.