Blood serum bitter taste receptors and total IgE in allergic bronchial asthma in women

Mineev V.N., Trofimov V.I., Sorokina L.N., Nyoma M.A., Kuzikova A.A.

Pavlov First St-Petersburg State Medical University, Saint-Petersburg

To date, expression of bitter taste receptors (TAS2R) in the respiratory system has been revealed, but in many respects the function of these receptors remains unclear. The aim is to determine the le vel of bitter taste receptors TAS2R38 and IgE in the blood serum in allergic bronchial asthma (BA) in women.
Materials and methods. We examined 23 practically healthy women and 29 patients with allergic asthma. The expression of blood serum level of TAS2R38 and total IgE was determined by the enzyme immunoassay.
Results. The level of TAS2R38 in women with allergic asthma is significantly less than in the group of healthy women. Factor analysis revealed a high negative factor load of the TAS2R38 component and a high positive factor load of the IL-4 and IL-13 component relative to the IgE component.
Conclusion. It has been suggested that soluble TAS2R38 receptors in allergic bronchial asthma seem to play a protective role in regulating not only the synthesis of IgE, but also the synthesis of a number of cytokines, primarily proinflammatory ones, by producer cells.