The factors of intercellular cooperation in immunogenesis of pyelonephritis

Drannik G.N., Driyanska V.E., Gaysenyuk F.Z., Rudenko M.Yu., Stepanova N.M., Bagdasarova I.V., Savchenko V.S., Lavrenchuk O.V., Rudenko A.V., Kruglikov V.T.

Institute of Nephrology NAMS of Ukraine
Institute of Urology NAMS of Ukraine
National Medical Academy of Postgraduate Education name P.L.Shupyk, Kiev, Ukraine

The study showed the increase in the level of pro- (IL-1,-17, -18, -23, TNF, MCP-1) and anti-inflammatory cytokines (IL-4, TGF), secretory leucocyte protease inhibitor (SLPI), the number of cells expressing the intercellular adhesion molecule-1 – ICAM-1 (CD54+) in patients with pyelonephritis (PN), peculiarities in acute and chronic PN. The high SLPI level was stated in serum and urine, which can be used, like the cytokine production, as an additional diagnostic and prognostic markers during the process of treatment.