The influence of the inflammatory process on immunologic factors in type 2 diabetic patients with rhinosinusitis and inflammation of middle ear

Shkurova N.A., Baranova N.I.

PIFTPh – Branch Campus of the FSBEI FPE RМАСРЕ МОН Russia, Penza, Russia

Background: To study the effect of the inflammatory process on immunologic factors in patients with rhinosinusitis and inflammation of middle ear having diabetes melitus-2.
Methods: 40 patients with acute rhinosinusitis and inflammation of middle ear were examined. As well as 36 patients with chronic rhinosinusitis and chronic inflammation of middle ear were examined too. We assessed the difference of spontaneous photosum (PCC-test): immunoglobulins A, M, G, E; cytokins: IL-1β, IL-17, IL-18, TGF-β, TNF-α, IL-4, IL-10, INF-γ in blood serum by IFA method.
Results: Immune deviations were of the same type in the most cases in patients with acute and chronic rhinosinusitis and inflammation of middle ear. The differences were detected in decreasing the levels IL-4, IL-17, INF-γ in patients chronic rhinosinusitis and inflammation of middle ear in comparison with acute cases.