Clinical-biochemical characteristics and indirect liver fibrosis markers in HCV-infected pregnant women

Znovets T.V., Zhavoronok S.V., Baranovskaya E.I., Kuznetsov Ya.O., Znovets I.A., Ataman A.V.

1 Belarusian State Medical University, Minsk, Republic of Belarus
2 5th city clinical polyclinic, Minsk, Republic of Belarus
3 9th city polyclinic, Minsk, Republic of Belarus

Biochemical features and clinical significance of indirect hepatic fibrosis markers were studied in 144 pregnant women with verified hepatitis C (group 1) and 111 pregnant women without laboratory markers of viral infections with the parenteral transmission mechanism (group 2). The results of the association of HCV infection with an increase in indirect markers of liver fibrosis in pregnant women (APRI and FIB-4 indices) associated with complications of pregnancy, childbirth and the postpartum period and concomitant pregnancy diseases were obtained. Changes in blood biochemical parameters in pregnant women with hepatitis C are caused by virological features of HCV infection, long-term course of HIV infection (p=0.015) and short course of antiretroviral therapy before pregnancy (p=0.005), associated with ultrasound pathology of the hepatobiliary system.