Human normal immunoglobulin for intravenous administration: indications, effectiveness and safety of clinical application

Potapnev M.P., Karpenko F.N.

Republican Center for Transfusiology & Medical BioTechnologies, Belarus

Normal human immunoglobulin for intravenous administration (IVIG) is widely used in medical practice.
First indication for IVIG application was primary immunodeficiency with hypogammaglobulinemia and risk of infection. More than 50% indications for IVIG use are related recently with its immunomodulatory effects. They are sepsis and septic conditions, tissue and organ transplantation, oncological, neurological, rheumatoid, allergic diseases, systemic vasculitis, coagulopathy, recurrent spontaneous abortion and others. Results of efficiency and safety of IVIG use in different disease sate are described. Adverse effects of IVIG clinical applications have a frequency of 5-15% of patients. Their classifications, frequency, predisposing factors, measures for preventive measures are presented. To decrease frequency and severity of adverse effects of IVIG subcutaneous route of administration were used instead of intravenous. This and others measures are considering now as essential to save clinical efficacy and decrease adverse effects of IVIG clinical use.