Comparative analysis of IL-4, IL-10, IL-6, IL-8 cytokines in nonalergic bronchial asthma and chronic obstructive pulmonary disease

Trushina E.Yu., Kostina E.M., Baranova N.I., Molotilov B.A., Tipikin V.A.

The Penza Institute for Further Training of Physicians – Branch Campus of the Federal State Budgetary Educational Institution of Further Professional Education «Russian Medical Academy of Continuous Professional Education» of the Ministry of Healthcare of the Russian Federation, Penza

163 people participated in the study. The study purpose was comparative analysis of spontaneous and induced production of IL-4, IL-10, IL-6, IL-8 in serum of patients with non-allergic bronchial asthma form (NABA) and chronic obstructive pulmonary disease (COPD). The investigative material was the spontaneous and phytohemaglutenin-induced production supernatant of the patient`s cells.
In the basis of neutrophilic inflammation in patients with NABA and COPD, both spontaneous and induced production of IL-6 and IL-8 cytokines play a leading role (p<0.05). IL-8 values were higher in COPD, whereas IL-6 production dominated in NABA (p<0.05). IL-4 and IL-10 levels were higher in NABA patients (p<0.05). Studied cytokines play an important role in the pathogenesis of both asthma and COPD.