Immunoglobulin concentrations in a pediatric population affected by recurrent respiratory infections in the Mogilev region

Povorova O.V., Titova N.D.

Mogilev State University named after A.A. Kuleshov, Mogilev, Republic of Belarus;
Belarusian Medical Academy of Postgraduate Education, Minsk, Republic of Belarus

247 children affected by recurrent respiratory tract disorders aged 2-16 years were examined. The levels of immunoglobulins in serum and saliva were determined by enzyme immunoassay. There were no statistically significant differences in the concentrations of the IgG and its subclasses and IgM concentrations in three age groups. In children over six years old, the level of IgE was two times higher than in children 2-5 years old (p = 0.0001). In children 11-16 years old, the concentrations of IgA (p = 0.0237) and sIgA (p = 0.0467) is 1.2 and 1.4 higher than in children 2-10 years old, while at the age of 6 and 9 years, minimum IgA values were observed among children 2-13 years old and maximum sIgA concentrations. Statistically significant coefficient of correlations were determined: weak negative correlation for IgA / IgG3 and weak positive correlations between IgM / IgG2 (for children 2-5 years old, 2-16 years old), IgG / IgM children 2-10 years old, IgM / IgG1 (for children 2-10 years old, 2-16 years old), IgA / IgG2 and IgA / IgE for children 2-16 years old; moderate correlation coefficients were detected in each age group between IgA and IgM, between IgG / IgG2 , IgG / IgG3 , IgG / IgG4 ; strong positive statistically significant correlation between IgG / IgG1 for all age groups. A slight negative correlation was found between IgG and IgE for all age groups. Statistically significant differences in the concentration of immunoglobulins were detected in frequently ill children with recurrent respiratory tract infections: IgG are 1.4 times higher in children 6-10 years old, and IgG3 are 1.7 times higher; in children 2-16 years old IgE concentrations are higher – in 1.9 times.