Modern Salmonella subtyping methods in outbreak investigations

Egorova S.A., Kuleshov K.V., Kaftyreva L.A.

Saint-Petersburg Pasteur Institute, Saint-Petersburg, Russia
Federal budget institute of science "Central research institute for epidemiology", Federal service for surveillance consumers' rights protection and human well-being, Moscow,Russia
Federal State Budget Scientific Institution "Federal Scientific Center VIEV" (FSC VIEV), Moscow, Russia
State Educational Institution of the Higher Professional Education "North-Western state medical University
n.a. I.I. Mechnikov" of the Ministry of health of the Russian Federation, Saint-Petersburg, Russia

The review describes the current methods of Salmonella molecular subtyping (molecular serotyping, MLST, PFGE, MLVA, WGS) that are used in the surveillance and outbreak investigation. Their methodological basis and the degree of implementation in laboratory practice around the world are presented, with focus on the subtyping approaches based on whole genome sequencing and existing international data analysis platforms "Pathogene Detection" and "Enterobase".