Pecularities of clinical manifestation of psoriasis during therapy
of chronic hepatitis C virus infection

Konnov P.E., Konnova T.V., Golik O.O.

Samara state medical University, Samara, Russia

Objective: to identify the features of the course and clinical picture of psoriasis during antiviral treatment of HCV infection. On clinical bases of departments of infectious diseases with epidemiology and skin and venereal diseases of SamSMU, 41 patients were under supervision, with HCV in combination with psoriasis. Depending on the treatment of HCV infection, patients were divided into following groups: group I (n=14) - patients receiving therapy with direct antiviral access drugs, group II (n=16) – patients receiving peg-INF with ribaverine, group III (n=11) – patients without etiotropic therapy of HCV with traditional external therapy of psoriasis.
Conclusions: 1) the use of INF-α drugs in the treatment of HCV signifi cantly aggravated the course of psoriasis, and in some cases did not lead to the formation of a stable virological response; 2) pathogenetic therapy of HCV helped to stop the psoriatic process on the skin, but the preservation of HCV infection is a predictor of an unfavorable outcome of the course of HCV; 3) the shortcomings mentioned above were not noted in the group of patients treated with HCV direct antiviral access drugs.