Dynamics of the level of matrix metalloproteinase 8 and tissue type 1 inhibitor in acute kidney injury after cardiac surgery

Bykov A.S., Markelova E.V., Fomina O.I., Fisenko V.G., Nurtazina A.Yu.

I.M. Sechenov First Moscow State Medical University, Moscow, Russia
Pacific state medical university, Vladivostok, Russia

The problem of early postoperative complications after coronary artery bypass surgery remains unresolved, one of these complications is acute kidney injury (AKI), the prevalence of which according to different authors reaches 30%.

Aim: to evaluate the diagnostic and prognostic value in determining the level of matrix metalloproteinase 8 and their type 1 inhibitor (MMP-8, TIMP 1) in patients with acute kidney injury before and after cardiac surgery.

Materials and methods: serum of 120 patients with coronary heart disease before and after cardiac surgery, divided into 3 groups: with AKI (I gr.), with AKI and diabetes mellitus (II gr.), without renal complications (III gr.).

Results: an increase in serum MMP-8 concentration was registered during the development of AKI in I gr. (p<0,05), low MMP-8 level was detected before the operation in group II (p<0,05), an increase in the level of TIMP 1 after surgery was recorded in all groups at 7 day (p<0,05).