Intracellular receptor TLR3: structure and signaling

Prokhorenko I.R., Kosyakova N.I.

Institute of Basic Biological Problems of Russian Academy of Sciences, Federal Research Center, Pushchino Scientific Center for Biological Research RAS, Pushchino, Russia

Hospital of Pushchino Scientific Center, Russian Academy of Sciences, Pushchino, Russia

The TLR3 receptor serves as an activator of intracellular signaling system for response of many viruses. The review presents data on the structure, localization and mechanisms of activation of the TLR3 receptor by viral double-stranded RNA (dsRNA) or its synthetic analog – polyinosine-polycytidylic acid (poly(I:C)).