Psychoemotional state and filaggrin level in pregnant women with atopic dermatitis

Kandrashkina Y.A., Orlova E.A.

Penza Institute for Advanced Training of Doctors is a branch of the FSBEI CPE «RMACPE» of the Ministry of Health of the Russian Federation, Penza, Russia

Purpose of the study: to assess the psycho-emotional state and the level of filaggrin in the blood serum of pregnant women with exacerbation of atopic dermatitis (AtD).
Materials and methods. The study included 70 pregnant women with AtD, 20 non-pregnant women with AtD, 20 healthy pregnant women. A survey was conducted on the Beck Depression and Anxiety Scale. The filaggrin level in the blood serum was assessed by ELISA.
Research results. Serum filaggrin levels in pregnant women with AtD were significantly higher than in non-pregnant women with AD (p=0.007) and healthy pregnant women (p=0.001). The level of anxiety was increased in the groups with AtD compared with the group of healthy pregnant women (p=0.001). The level of depression in pregnant women with AtD was higher than in healthy pregnant women (p=0.002) and non-pregnant women with AtD (p=0.021).
Conclusions. It was found that pregnant women with AtD have more pronounced disorders of the psycho-emotional state and a higher level of filaggrin in the blood serum than non-pregnant women with AtD and healthy pregnant women.