Clinical and immunological monitoring of atopic dermatitis in children in Ulyanovsk oblast

Solovyova I.L., Kafarova A.I., Sokolova T.V., Panchenko L.A., Smirnova V.A.

Ulyanovsk State University, Ulyanovsk
Russian Biotechnological University, Moscow
Moscow State University named after M.V. Lomonosov, Moscow

Immune processes involving pro- and anti-inflammatory cytokines play an important role in the pathogenesis of atopic dermatitis (AD).

Aim. To study the correlation of immune-inflammatory markers with the clinical picture of AD in children.

Methods. The study involved children aged 2 to 12 years old with acute AD. The levels of total and specific IgE, IL-2, IL-8, IL-31, INF-γ, TGF-β1, VEGF were determined by means of enzyme immunoassay. Correlation analysis was used to assess the correlation between the clinical characteristics of AD and immune markers of inflammation.

Results. The examination of 90 children with AD revealed an increase in the levels of IL-8, IL-31, INF-γ, VEGF, TGF-β1 (p≤0.001). There was a correlation of the clinical form of AD and the prevalence of the skin-pathological process with the level of INF-γ (r=0.28 / r=0.26) and the number of identified allergens (r=0.30 / r=0.29); severity of AD on the SCORAD scale with the level of IgE (r=0.39); hereditary predisposition (r=0.33) and atopic march (r=0.32) – with the level of TGF-β1; chronization of the process – with the levels of IL-2 (r=0.54) and IL-8 (r=0.34).

Conclusions. Clinical and immunological parallels in AD in children indicate a pathogenetic relationship between clinical and selected immunological criteria of the disease.