The role of interleukins 31 and 33 in the pathogenesis of atopic dermatitis during pregnancy

Kandrashkina Y.A., Orlova E.A., Shtach A.F.

Penza Institute for Advanced Training of Doctors is a branch of the FSBEI CPE «RMACPE» of the Ministry of Health of the Russian Federation, Penza, Russia

Aim of the study: to study the role of IL-31 and IL-33 in the pathogenesis of atopic dermatitis (AtD) during pregnancy.

Materials and methods. The study included 76 pregnant women with AtD, 20 non–pregnant women with AtD, 20 healthy pregnant women and 20 healthy non–pregnant women. The diagnosis of AtD was established based on criteria according to clinical guidelines. The level of IL-31 and IL-33 in the blood serum was assessed by ELISA, pruritus – according to the itch scale 5D.

Research results. The mean value of the level of IL-31 in the group of pregnant women with AtD was significantly higher (46.87±7.67 pg/ml) (Mann-Whitney test, p<0.05) than in the control groups. The level of IL-33 in pregnant women with AtD was significantly higher (5.1±0.26 pg/ml) than in healthy pregnant and non – pregnant women (Mann-Whitney test, p<0.05). The correlation between IL-31, IL-33, and pruritus was determined.

Conclusion. The results obtained and further in–depth study of the pathogenesis of AtD during pregnancy may improve the tactics of management and treatment of pregnant women with AtD.