Influence of pharmacological agents inhibiting hyperimmune response on activity and morphometric indicators of liver function

Ziamko V.Y., Dzyadzko A.M., Kanevalava N.U.

Vitebsk State Medical University, Belarus
Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology, Belarus

Aim: to study influence of drugs that inhibit hyperimmune response on morphological and functional changes in the liver.
Materials and methods. We conducted an experimental study on 26 male Wistar rats with body weight of 250-350 g., which were divided in 5 groups: 3 experimental, 1 control and 1 intact. Polyvinylpyrrolidone, human recombinant C1 inhibitor, interleukin-6 inhibitor at a dose per kg of body weight were used as pharmacological agents. On the 14th day rats were taken out of the experiment with subsequent blood sampling for biochemical and liver - for histological studies.
Results and discussion. C1-inhibitor and interleukin-6 inhibitor lead to a decrease in the area of hepatocytes and their nuclei, however, exposure to the latter stimulates liver proliferation by increasing the number of binuclear hepatocytes. Polyvinylpyrrolidone and interleukin-6 inhibitor cause an increase of transaminases, amylase and urea, at the same time having a positive effect on electrolyte metabolism.
Conclusion. The investigated pharmacological agents accumulated in Kupffer cells do not damage the intact liver but cause its dysfunction in systemic inflammatory response.