Antifungal resistance of dermatophytes and pitfalls in treatment of superficial mycoses

Sergeev A.Y.

Novosibirsk State University, Russia
All-Russian National Academy of Mycology, Moscow, Russia

Treatment of dermatomycoses has faced numerous challenges as of late, one of the key reasons for which being the emerging resistance of pathogenic fungi to antifungal drugs. A vivid variety of resistance mechanisms found in dermatophytes has rendered certain methods to determine clinically significant resistance unreliable. Epidemiological studies conducted in India and other countries over the recent years suggest a possible etiological change in several forms of dermatophyte infections, as well as a global spread of resistant ‘mutant’ strains. Shared experience of foreign researchers allows for a proposition of novel measures aimed to combat persistent dermatophyte infection. The measures in question include limited use of topical corticosteroids and introduction of combination antifungal treatment, comprising antifungals with fungicidal potential and anti-inflammatory properties, such as naftifine.