Toll-like receptors and primary pathogen recognition in infectious and non-infectious cutaneous pathology

Sorokina E.V.

Toll-like receptors (TLRs) are a class of conserved receptors that recognize pathogen-associated molecular patterns (PAMPs) present in microbes. Of dermatological interest, these receptors are expressed on several skin cells including keratinocytes, melanocytes, and Langerhans cells. In addition, the role of TLRs in cutaneous host defense mechanisms against a variety of microorganisms, including bacteria, fungi, and viruses, as well as the involvement of TLRs in the pathogenesis of certain skin diseases will be discussed in review.