The influence of clinical and anamnestical peculiarities of psoriasis vulgaris on the immunological pathways

Baytyakov V.V., Novikova L.V.

Two hundred fifty three patients with extensive psoriasis vulgaris from the age of 18 to 72 have been observed. Study of indices of natural constitutive and adaptive immunity in patients with the exacerbation of extensive psoriasis, the investigation of the immune disorders dependence on the clinical peculiarities of the disease and anamnesis data.
The state of cellular and humoral adaptive immunity, disorders in phagocytic processe and the synthesis of some cytokines have been evaluated.
Rise of the total number of lymphocytes, CD3+-lymphocytes, and helper cells, the increase in the levels of immunoglobulins M and A, circulating immune complexes, tumour-a necrosis factor, interleukin-2, the increase in the activity of neutrophil protection component have been marked. The dependence of some immunological indices on the sex, age, family history, severity of skin process, nails damage has been revealed. The increase in helper cell activity and the decrease in suppressor T-lymphocyte activity as well as the increase in the levels of immunoglobulins M, the complement activity and circulating immune complexes are indirectly evident of autoimmune character of the process.