Antimicrobial and immunomodulatory activity of resveratrol and resveratrol- containing plant derivatives

Korotina O.L., Zubareva I.V., Yupatov Yu.G., Moiseev D.V., Generalov I.I

Vitebsk State Medical University
SHU VCCP V.I.Lenin’s Policlinics № 4, Vitebsk

The main goal of the study implied the assessment of antimicrobial and immunomodulatory activity of phytoalexin resveratrol, its solubilizer (ethanol) and resveratrol-containing plant derivatives. Primarily, the methods for quantitative determination of resveratrol as well as the methods of extraction of resveratrol- enriched plant derivatives were elaborated. A broad screening of resveratrol in food and non-food plant raw was performed. Resveratrol content in extractions from red grape skins (Vitis vinifera) was determined by high performance liquid chromatography (HPLC) analysis. For the first time the elevated quantity of resveratrol was found in the roots of herb Polygonum tataricum. Analysis of other studied Polygonum species didn’t reveal the presence of resveratrol. Resveratrol and resveratrol-containing extractions demonstrated the modest antimicrobial action against some infectious agents: pseudomonads, bacilli, Candida albicans fungi. For these pathogens minimal inhibitory concentration of resveratrol was found to be 100 ug/ml or more. At the same time resveratrol and its solubilizer (ethanol) exhibited evident anti-proliferative effects in lymphocyte cell cultures and noticeably suppressed phagocytosis. In addition, resveratrol completely inhibited IgG abzymes with peroxidase activity, whereas its influence on DNAse abzymes was variable.