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International journal of Immunopathology, allergology, infectology.

Role of chronic viral hepatitis in development of liver cirrhosis and hepatocellular carcinoma

Gromova N.I.

Epidemiological, physical and laboratory examination of 578 patients with viral hepatitis B, C and Delta was conducted in order to determine the incidence of irreversible changes in liver tissue of patients with these conditions. 58/578 patients had confirmed liver cirrhosis of viral etiology. Incidence of liver cirrhosis varied significantly between groups of patients with viral hepatitis of different etiology. It was 14,3% in patients with chronic hepatitis C (CHC) and 7% in patients with chronic hepatitis B (CHB) without Delta infection, whereas among patients with CHB and Delta infection it was 10 times higher 73,3%. Additionally, the incidence of hepatocellular carcinoma in patients with CHB was higher then in patients with CHC 23,8% and 13,5%, respectively. In patients with CHB-associated liver cirrhosis lethality rate was higher (42,9%) then in patients with CHC-associated cirrhosis (16,2%).


Chronic hepatitis B, C and Delta; liver cirrhosis; hepatocellular carcinoma; natural history; treatment effectiveness.

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Gromova N.I. Immunopathology, allergology, infectology 2012; 1:37-44